Involvement of cholinergic, adrenergic, and glutamatergic network modulation with cognitive dysfunction in Alzheimer's disease

YJ Cheng, CH Lin, HY Lane - International Journal of Molecular Sciences, 2021 - mdpi.com
… We also discuss the key role of N-methyl-d-aspartate receptor (… In the brains of patients
with Alzheimer-type dementia, the … d-cycloserine can facilitate NMDAR–ionophore complex

Ultimate translation: developing therapeutics targeting on N-methyl-d-aspartate receptor

GE Tsai - Advances in Pharmacology, 2016 - Elsevier
… , aging, mild cognitive impairment and Alzheimer's dementia, … has no specific transporter
across the blood–brain barrier. … , and the magnitude of d-cycloserine-facilitated virtual reality …

Modulating the balance of synaptic and extrasynaptic NMDA receptors shows positive effects against amyloid-β-induced neurotoxicity

Y Huang, W Shen, J Su, B Cheng, D Li… - … of Alzheimer's …, 2017 - content.iospress.com
… In AD patients, the N-methyl-D-aspartate (NMDA)-… putative cognitive enhancer, D-cycloserine
(a co-activator of NMDRs similar to D-serine) facilitates activation of NMDA in the AD brain

Glutamatergic neurotransmission: A potential pharmacotherapeutic target for the treatment of cognitive disorders

P Chakraborty, A Dey, AV Gopalakrishnan… - Ageing Research …, 2023 - Elsevier
… formulate a complex glutamatergic network in the brain that … The iGluRs include N-methyl-D-aspartate
(NMDA), α-amino-3… the NMDA ion channel pore and facilitate the passage of Ca 2 …

Targeted treatment of individuals with psychosis carrying a copy number variant containing a genomic triplication of the glycine decarboxylase gene

JA Bodkin, MJ Coleman, LJ Godfrey, CMB Carvalho… - Biological …, 2019 - Elsevier
N-methyl-D-aspartate receptor augmentation of psychotropic drug treatment in these two
individuals. Glycine was used in the first clinical trial, and D-cycloserine … levels of brain glycine …

Antimicrobial therapy and the potential mechanisms in Alzheimer's disease

X Song, J Chen, Z Hou, N Xie - Neuroscience Letters, 2021 - Elsevier
cerebral brain flow (CBF). Secondly, rapamycin promotes the degradation of Aβ and Tau by
activating … shed light on that d-cycloserine improved difficult discriminations in the pattern …

Exploiting the therapeutic potential of ready-to-use drugs: Repurposing antibiotics against amyloid aggregation in neurodegenerative diseases

SB Socias, F Gonzalez-Lizarraga, CL Avila… - Progress in …, 2018 - Elsevier
… affect specific regions of the brain, causing gradual disability and … In fact, according to a
systematic study only on Alzheimer’s … D-Cycloserine (DCS) is an antibiotic widely prescribed for …

[HTML][HTML] Antibiotics and antivirals for dementia and mild cognitive impairment

Y Zhou, M Yang, BR Dong, T Chen… - The Cochrane Database …, 2018 - ncbi.nlm.nih.gov
… (except Dcycloserine) and antiviral agents for dementia. … and cognitive enhancement in
healthy and in those with mild … in the brains of Alzheimer patients, but not the brains of patients …

Anti-NMDA and Anti-AMPA Receptor Antibodies in Central Disorders: Preclinical Approaches to Assess Their Pathological Role and Translatability to Clinic

G Olivero, A Roggeri, A Pittaluga - International Journal of Molecular …, 2023 - mdpi.com
… of patients suffering from brain disorders characterized by … neurodegenerative disorders
including Alzheimer’s disease (… C1q binds the antibody–antigen complexes and activates an …

Functional characterization of a novel NMDA receptor positive allosteric modulator

V Li - 2017 - open.library.ubc.ca
N-methyl D-aspartate (NMDA) receptors are ionotropic glutamatergic receptors key in regulating
normal brain … schizophrenia and Alzheimer’s disease, or for application as a cognitive